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Article

Novel genes identified in a high-density genome wide association study for nicotine dependence.

Human molecular genetics - 1 Jan 2007

Bierut Laura Jean, Madden Pamela A F, Breslau Naomi, Johnson Eric O, Hatsukami Dorothy, Pomerleau Ovide F, Swan Gary E, Rutter Joni, Bertelsen Sarah, Fox Louis, Fugman Douglas, Goate Alison M, Hinrichs Anthony L, Konvicka Karel, Martin Nicholas G, Montgomery Grant W, Saccone Nancy L, Saccone Scott F, Wang Jen C, Chase Gary A, Rice John P, Ballinger Dennis G

Abstract excerpt

Tobacco use is a leading contributor to disability and death worldwide, and genetic factors contribute in part to the development of nicotine dependence. To identify novel genes for which natural variation contributes to the development of nicotine dependence, we performed a comprehensive genome wide association study using nicotine dependent smokers as cases and non-dependent smokers as controls. To allow the...

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Source

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Identifiers

PMID: 17158188
DOI: 10.1093/hmg/ddl441
PMCID: PMC2278047

Genes

NRXN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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