Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Uncovering the DNA methylation landscape in key regulatory regions within the FADS cluster.

PloS one - 1 Jan 2017

Rahbar Elaheh, Ainsworth Hannah C, Howard Timothy D, Hawkins Gregory A, Ruczinski Ingo, Mathias Rasika, Seeds Michael C, Sergeant Susan, Hixson James E, Herrington David M, Langefeld Carl D, Chilton Floyd H

Abstract excerpt

Genetic variants near and within the fatty acid desaturase (FADS) cluster are associated with polyunsaturated fatty acid (PUFA) biosynthesis, levels of several disease biomarkers and risk of human disease. However, determining the functional mechanisms by which these genetic variants impact PUFA levels remains a challenge. Utilizing an Illumina 450K array, we previously reported strong allele-specific methylation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Black or African American
Share to CpG Islands

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Delta-5 Fatty Acid Desaturase

Share to Demography

Share to DNA Methylation

Share to Fatty Acid Desaturases

Share to Multigene Family

Share to Regulatory Sequences, Nucleic Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 28957329
DOI: 10.1371/journal.pone.0180903
PMCID: PMC5619705

Genes

FADS1
FADS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Uncovering the DNA methylation landscape in key regulatory regions within the FADS cluster.PMID 28957329Read ↗

DNA methylation in an enhancer region of the FADS cluster is associated with FADS activity in human liver.Semantic proximity Read ↗

Allele-specific methylation in the FADS genomic region in DNA from human saliva, CD4+ cells, and total leukocytes.Semantic proximity Read ↗

FADS1-FADS2 genetic polymorphisms are associated with fatty acid metabolism through changes in DNA methylation and gene expression.Semantic proximity Read ↗

Liver DNA methylation of FADS2 associates with FADS2 genotypexSemantic proximity Read ↗

Tissue-specific impact of FADS cluster variants on FADS1 and FADS2 gene expression.Semantic proximity Read ↗

Identification of a functional FADS1 3'UTR variant associated with erythrocyte n-6 polyunsaturated fatty acids levels.Semantic proximity Read ↗

Insertion-deletions in a FADS2 intron 1 conserved regulatory locus control expression of fatty acid desaturases 1 and 2 and modulate response to simvastatin.Semantic proximity Read ↗

Fatty acid desaturase 1 gene polymorphisms control human hepatic lipid composition.Semantic proximity Read ↗

A regulatory insertion-deletion polymorphism in the FADS gene cluster influences PUFA and lipid profiles among Chinese adults: a population-based study.Semantic proximity Read ↗

A common FADS2 promoter polymorphism increases promoter activity and facilitates binding of transcription factor ELK1.Semantic proximity Read ↗

FADS genetic variants and omega-6 polyunsaturated fatty acid metabolism in a homogeneous island population.Semantic proximity Read ↗

FADS genetic and metabolomic analyses identify the ∆5 desaturase (FADS1) step as a critical control point in the formation of biologically important lipids.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.