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Article

Insertion-deletions in a FADS2 intron 1 conserved regulatory locus control expression of fatty acid desaturases 1 and 2 and modulate response to simvastatin.

Prostaglandins, leukotrienes, and essential fatty acids - 1 Jul 2012

Reardon Holly T, Zhang Jimmy, Kothapalli Kumar S D, Kim Andrea J, Park Woo Jung, Brenna J Thomas

Abstract excerpt

The fatty acid desaturase genes (FADS1 and FADS2) code for enzymes required for synthesis of omega-3 and omega-6 long-chain polyunsaturated fatty acids (LCPUFA) important in the central nervous system, inflammatory response, and cardiovascular health. SNPs in these genes are associated with numerous health outcomes, but it is unclear how genetic variation affects enzyme function. Here, lymphoblasts obtained from...

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Source

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Identifiers

PMID: 22748975
DOI: 10.1016/j.plefa.2012.04.011
PMCID: PMC3404253

Genes

FADS2
FADS1

Provenance

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Related research

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Insertion-deletions in a FADS2 intron 1 conserved regulatory locus control expression of fatty acid desaturases 1 and 2 and modulate response to simvastatin.PMID 22748975Read ↗

A regulatory insertion-deletion polymorphism in the FADS gene cluster influences PUFA and lipid profiles among Chinese adults: a population-based study.Semantic proximity Read ↗

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A common FADS2 promoter polymorphism increases promoter activity and facilitates binding of transcription factor ELK1.Semantic proximity Read ↗

Tissue-specific impact of FADS cluster variants on FADS1 and FADS2 gene expression.Semantic proximity Read ↗

FADS1-FADS2 genetic polymorphisms are associated with fatty acid metabolism through changes in DNA methylation and gene expression.Semantic proximity Read ↗

Genetic variants of the FADS1 FADS2 gene cluster as related to essential fatty acid metabolism.Semantic proximity Read ↗

Fatty acid desaturase 1 gene polymorphisms control human hepatic lipid composition.Semantic proximity Read ↗

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FADS1 and FADS2 Polymorphisms Modulate Fatty Acid Metabolism and Dietary Impact on HealthSemantic proximity Read ↗

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