A regulatory insertion-deletion polymorphism in the FADS gene cluster influences PUFA and lipid profiles among Chinese adults: a population-based study.

doi:10.1093/ajcn/nqy063

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Article

A regulatory insertion-deletion polymorphism in the FADS gene cluster influences PUFA and lipid profiles among Chinese adults: a population-based study.

The American journal of clinical nutrition - 1 Jun 2018

Li Peiqin, Zhao Jing, Kothapalli Kumar S D, Li Xiang, Li Hui, Han Yuxuan, Mi Shengquan, Zhao Wenhua, Li Qizhai, Zhang Hong, Song Yiqing, Brenna J Thomas, Gao Ying

Abstract excerpt

Background: Arachidonic acid (AA) is the major polyunsaturated fatty acid (PUFA) substrate for potent eicosanoid signaling to modulate inflammation and thrombosis and is controlled in part by tissue abundance. Fatty acid desaturase 1 (FADS1) catalyzes synthesis of omega-6 (n-3) AA and n-3 eicosapentaenoic acid (EPA). The rs66698963 polymorphism, a 22-base pair (bp) insertion-deletion 137 bp downstream of a sterol...

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PMID: 29746616
DOI: 10.1093/ajcn/nqy063

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FADS1
FADS2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A regulatory insertion-deletion polymorphism in the FADS gene cluster influences PUFA and lipid profiles among Chinese adults: a population-based study.PMID 29746616Read ↗

Hypothesis: the rs66698963 insertion-deletion alters the AA/EPA ratio and cardiovascular disease risk.Semantic proximity Read ↗

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Positive Selection on a Regulatory Insertion-Deletion Polymorphism in FADS2 Influences Apparent Endogenous Synthesis of Arachidonic Acid.Semantic proximity Read ↗

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