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Article

Tissue-specific impact of FADS cluster variants on FADS1 and FADS2 gene expression.

PloS one - 1 Jan 2018

Reynolds Lindsay M, Howard Timothy D, Ruczinski Ingo, Kanchan Kanika, Seeds Michael C, Mathias Rasika A, Chilton Floyd H

Abstract excerpt

Omega-6 (n-6) and omega-3 (n-3) long (≥ 20 carbon) chain polyunsaturated fatty acids (LC-PUFAs) play a critical role in human health and disease. Biosynthesis of LC-PUFAs from dietary 18 carbon PUFAs in tissues such as the liver is highly associated with genetic variation within the fatty acid desaturase (FADS) gene cluster, containing FADS1 and FADS2 that encode the rate-limiting desaturation enzymes in the...

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Share to Delta-5 Fatty Acid Desaturase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 29590160
DOI: 10.1371/journal.pone.0194610
PMCID: PMC5874031

Genes

FADS1
FADS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Tissue-specific impact of FADS cluster variants on FADS1 and FADS2 gene expression.PMID 29590160Read ↗

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