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Article

A common FADS2 promoter polymorphism increases promoter activity and facilitates binding of transcription factor ELK1.

Journal of lipid research - 1 Jan 2010

Lattka E, Eggers S, Moeller G, Heim K, Weber M, Mehta D, Prokisch H, Illig T, Adamski J

Abstract excerpt

Fatty acid desaturases (FADS) play an important role in the formation of omega-6 and omega-3 highly unsaturated fatty acids (HUFAs). The composition of HUFAs in the human metabolome is important for membrane fluidity and for the modulation of essential physiological functions such as inflammation processes and brain development. Several recent studies reported significant associations of single nucleotide...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 19546342
DOI: 10.1194/jlr.M900289-JLR200
PMCID: PMC2789778

Genes

FADS2
ELK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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A common FADS2 promoter polymorphism increases promoter activity and facilitates binding of transcription factor ELK1.PMID 19546342Read ↗

Insertion-deletions in a FADS2 intron 1 conserved regulatory locus control expression of fatty acid desaturases 1 and 2 and modulate response to simvastatin.Semantic proximity Read ↗

Identification of a functional FADS1 3'UTR variant associated with erythrocyte n-6 polyunsaturated fatty acids levels.Semantic proximity Read ↗

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Genetic variants of the FADS1 FADS2 gene cluster as related to essential fatty acid metabolism.Semantic proximity Read ↗

Tissue-specific impact of FADS cluster variants on FADS1 and FADS2 gene expression.Semantic proximity Read ↗

FADS1 and FADS2 Polymorphisms Modulate Fatty Acid Metabolism and Dietary Impact on HealthSemantic proximity Read ↗

Fatty acid desaturase 1 gene polymorphisms control human hepatic lipid composition.Semantic proximity Read ↗

Uncovering the DNA methylation landscape in key regulatory regions within the FADS cluster.Semantic proximity Read ↗

Functional Impact of the FADS1 rs174546 Single Nucleotide Polymorphism on Serum Lipid Levels: Insights from Molecular Mechanisms and Therapeutic Perspectives in Korean Population.Semantic proximity Read ↗

DNA methylation in an enhancer region of the FADS cluster is associated with FADS activity in human liver.Semantic proximity Read ↗

FADS1 genotype is distinguished by human subcutaneous adipose tissue fatty acids, but not inflammatory gene expression.Semantic proximity Read ↗

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