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Article

FADS genetic and metabolomic analyses identify the ∆5 desaturase (FADS1) step as a critical control point in the formation of biologically important lipids.

Scientific reports - 28 Sept 2020

Reynolds Lindsay M, Dutta Rahul, Seeds Michael C, Lake Kirsten N, Hallmark Brian, Mathias Rasika A, Howard Timothy D, Chilton Floyd H

Abstract excerpt

Humans have undergone intense evolutionary selection to optimize their capacity to generate necessary quantities of long chain (LC-) polyunsaturated fatty acid (PUFA)-containing lipids. To better understand the impact of genetic variation within a locus of three FADS genes (FADS1, FADS2, and FADS3) on a diverse family of lipids, we examined the associations of 247 lipid metabolites (including four major classes...

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Identifiers

PMID: 32985521
DOI: 10.1038/s41598-020-71948-1
PMCID: PMC7522985

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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