Article
Allele-specific methylation in the FADS genomic region in DNA from human saliva, CD4+ cells, and total leukocytes.
Clinical epigenetics - 1 Jan 2018
Rahbar Elaheh, Waits Charlotte Mae K, Kirby Edward H, Miller Leslie R, Ainsworth Hannah C, Cui Tao, Sergeant Susan, Howard Timothy D, Langefeld Carl D, Chilton Floyd H
Abstract excerpt
Background: Genetic variants within the fatty acid desaturase (FADS) gene cluster (human Chr11) are important regulators of long-chain (LC) polyunsaturated fatty acid (PUFA) biosynthesis in the liver and consequently have been associated with circulating LC-PUFA levels. More recently, epigenetic modifications such as DNA methylation, particularly within the FADS cluster, have been shown to affect LC-PUFA levels....
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