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Article

Identification of a functional FADS1 3'UTR variant associated with erythrocyte n-6 polyunsaturated fatty acids levels.

Journal of clinical lipidology - 1 Jan 2000

Hermant Xavier, Delay Charlotte, Flaig Amandine, Luque-Bedregal Jimena, Briand Gilbert, Bout Marie-Adélaïde, Cottel Dominique, Wagner Aline, Arveiler Dominique, Simon Chantal, Ferrières Jean, Ruidavets Jean-Bernard, Laillet Brigitte, Amouyel Philippe, Dallongeville Jean, Meirhaeghe Aline, Dumont Julie

Abstract excerpt

BACKGROUND: Blood polyunsaturated fatty acid (PUFA) levels are determined by diet and by endogenous synthesis via Δ5- and Δ6-desaturases (encoded by the FADS1 and FADS2 genes, respectively). Genome-wide association studies have reported associations between FADS1-FADS2 polymorphisms and the plasma concentrations of PUFAs, HDL- and LDL-cholesterol, and triglycerides. However, much remains unknown regarding the...

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Identifiers

PMID: 30170993
DOI: 10.1016/j.jacl.2018.07.012

Genes

FADS1
FADS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of a functional FADS1 3'UTR variant associated with erythrocyte n-6 polyunsaturated fatty acids levels.PMID 30170993Read ↗

Association between FADS1 rs174547 and levels of long-chain PUFA: a meta-analysis.Semantic proximity Read ↗

Interaction between a common variant in FADS1 and erythrocyte polyunsaturated fatty acids on lipid profile in Chinese Hans.Semantic proximity Read ↗

Single nucleotide polymorphisms in the FADS gene cluster are associated with delta-5 and delta-6 desaturase activities estimated by serum fatty acid ratios.Semantic proximity Read ↗

Insertion-deletions in a FADS2 intron 1 conserved regulatory locus control expression of fatty acid desaturases 1 and 2 and modulate response to simvastatin.Semantic proximity Read ↗

FADS genetic variants and omega-6 polyunsaturated fatty acid metabolism in a homogeneous island population.Semantic proximity Read ↗

Genetic variants of the FADS1 FADS2 gene cluster as related to essential fatty acid metabolism.Semantic proximity Read ↗

FADS2 polymorphisms are associated with plasma arachidonic acid and estimated desaturase-5 activity in a cross-sectional study.Semantic proximity Read ↗

Genetic variation at the FADS1-FADS2 gene locus influences delta-5 desaturase activity and LC-PUFA proportions after fish oil supplementSemantic proximity Read ↗

A common FADS2 promoter polymorphism increases promoter activity and facilitates binding of transcription factor ELK1.Semantic proximity Read ↗

Dietary linoleic acid interacts with FADS1 genetic variability to modulate HDL-cholesterol and obesity-related traits.Semantic proximity Read ↗

FADS1 gene polymorphism(s) and fatty acid composition of serum lipids in adolescents.Semantic proximity Read ↗

FADS genetic and metabolomic analyses identify the ∆5 desaturase (FADS1) step as a critical control point in the formation of biologically important lipids.Semantic proximity Read ↗

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