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Article

DNA methylation in an enhancer region of the FADS cluster is associated with FADS activity in human liver.

PloS one - 1 Jan 2014

Howard Timothy D, Mathias Rasika A, Seeds Michael C, Herrington David M, Hixson James E, Shimmin Lawrence C, Hawkins Greg A, Sellers Matthew, Ainsworth Hannah C, Sergeant Susan, Miller Leslie R, Chilton Floyd H

Abstract excerpt

Levels of omega-6 (n-6) and omega-3 (n-3), long chain polyunsaturated fatty acids (LcPUFAs) such as arachidonic acid (AA; 20:4, n-6), eicosapentaenoic acid (EPA; 20:5, n-3) and docosahexaenoic acid (DHA; 22:6, n-3) impact a wide range of biological activities, including immune signaling, inflammation, and brain development and function. Two desaturase steps (Δ6, encoded by FADS2 and Δ5, encoded by FADS1) are rate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24842322
DOI: 10.1371/journal.pone.0097510
PMCID: PMC4026313

Genes

FADS1
FADS2
CRP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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DNA methylation in an enhancer region of the FADS cluster is associated with FADS activity in human liver.PMID 24842322Read ↗

Uncovering the DNA methylation landscape in key regulatory regions within the FADS cluster.Semantic proximity Read ↗

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FADS genetic variants and omega-6 polyunsaturated fatty acid metabolism in a homogeneous island population.Semantic proximity Read ↗

Identification of a functional FADS1 3'UTR variant associated with erythrocyte n-6 polyunsaturated fatty acids levels.Semantic proximity Read ↗

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