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Article

Liver DNA methylation of FADS2 associates with FADS2 genotypex

17 Jan 2019

Abstract excerpt

BACKGROUND: Non-alcoholic fatty liver disease has been associated with increased mRNA expression of FADS2 in the liver and estimated activity of delta-6 desaturase in serum, encoded by the FADS2 gene. Since DNA methylation in the FADS1/2/3 gene cluster has been previously linked with genetic variants and desaturase activities, we now aimed to discover factors regulating DNA methylation of the CpG sites annotated...

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PMID: 30654845
DOI: 10.1186/s13148-019-0609-1

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