Article

A robust and efficient method for Mendelian randomization with hundreds of genetic variants: unravelling mechanisms linking HDL-cholesterol and coronary heart disease

2019-03-04

Abstract excerpt

Mendelian randomization (MR) investigations with large numbers of genetic variants are becoming increasingly common. However, the reliability of findings from a MR investigation is dependent on the validity of the genetic variants as instrumental variables. We developed a method to identify groups of genetic variants with similar causal effect estimates, which may represent distinct mechanisms by which the risk fa...

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Literature Corpus work: 7a5f8d5e-5e2c-54ea-a28a-3a1895056491
DOI: 10.1101/566851

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