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Article

Mendelian randomization analysis with multiple genetic variants using summarized data.

Genetic epidemiology - 1 Nov 2013

Burgess Stephen, Butterworth Adam, Thompson Simon G

Abstract excerpt

Genome-wide association studies, which typically report regression coefficients summarizing the associations of many genetic variants with various traits, are potentially a powerful source of data for Mendelian randomization investigations. We demonstrate how such coefficients from multiple variants can be combined in a Mendelian randomization analysis to estimate the causal effect of a risk factor on an outcome....

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Identifiers

PMID: 24114802
DOI: 10.1002/gepi.21758
PMCID: PMC4377079

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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