Article
Genetic risk scores and family history as predictors of schizophrenia in Nordic registers.
Psychological medicine - 1 May 2018
Lu Y, Pouget J G, Andreassen O A, Djurovic S, Esko T, Hultman C M, Metspalu A, Milani L, Werge T, Sullivan P F
Abstract excerpt
BACKGROUND: Family history is a long-standing and readily obtainable risk factor for schizophrenia (SCZ). Low-cost genotyping technologies have enabled large genetic studies of SCZ, and the results suggest the utility of genetic risk scores (GRS, direct assessments of inherited common variant risk). Few studies have evaluated family history and GRS simultaneously to ask whether one can explain away the other....
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