Genome-wide association study reveals greater polygenic loading for schizophrenia in cases with a family history of illness.

doi:10.1002/ajmg.b.32402

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Article

Genome-wide association study reveals greater polygenic loading for schizophrenia in cases with a family history of illness.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Mar 2016

Bigdeli Tim B, Ripke Stephan, Bacanu Silviu-Alin, Lee Sang Hong, Wray Naomi R, Gejman Pablo V, Rietschel Marcella, Cichon Sven, St Clair David, Corvin Aiden, Kirov George, McQuillin Andrew, Gurling Hugh, Rujescu Dan, Andreassen Ole A, Werge Thomas, Blackwood Douglas H R, Pato Carlos N, Pato Michele T, Malhotra Anil K, O'Donovan Michael C, Kendler Kenneth S, Fanous Ayman H

Abstract excerpt

Genome-wide association studies (GWAS) of schizophrenia have yielded more than 100 common susceptibility variants, and strongly support a substantial polygenic contribution of a large number of small allelic effects. It has been hypothesized that familial schizophrenia is largely a consequence of inherited rather than environmental factors. We investigated the extent to which familiality of schizophrenia is...

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PMID: 26663532
DOI: 10.1002/ajmg.b.32402
PMCID: PMC5816590

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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