Polygenic risk scores for schizophrenia and major depression are associated with socio-economic indicators of adversity in two British community samples.

Abstract excerpt

Schizophrenia (SCZ) and major depressive disorder (MDD) are complex psychiatric disorders which contribute substantially to the global burden of disease. Both psychopathologies are heritable with some genetic overlap between them. Importantly, SCZ and MDD have also been found to be associated with environmental risk factors. However, rather than being independent of genetic influences, exposure to environmental...

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