Article
Polygenic Risk Score, Parental Socioeconomic Status, Family History of Psychiatric Disorders, and the Risk for Schizophrenia: A Danish Population-Based Study and Meta-analysis.
JAMA psychiatry - 1 Jul 2015
Agerbo Esben, Sullivan Patrick F, Vilhjálmsson Bjarni J, Pedersen Carsten B, Mors Ole, Børglum Anders D, Hougaard David M, Hollegaard Mads V, Meier Sandra, Mattheisen Manuel, Ripke Stephan, Wray Naomi R, Mortensen Preben B
Abstract excerpt
IMPORTANCE: Schizophrenia has a complex etiology influenced both by genetic and nongenetic factors but disentangling these factors is difficult. OBJECTIVE: To estimate (1) how strongly the risk for schizophrenia relates to the mutual effect of the polygenic risk score, parental socioeconomic status, and family history of psychiatric disorders; (2) the fraction of cases that could be prevented if no one was...
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