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ING5 activity in self-renewal of glioblastoma stem cells via calcium and follicle stimulating hormone pathways

18 Sept 2017

Abstract excerpt

Stem cell-like brain tumor initiating cells (BTICs) cause recurrence of glioblastomas, with BTIC 'stemness' affected by epigenetic mechanisms. The ING family of epigenetic regulators (ING1-5) function by targeting histone acetyltransferase (HAT) or histone deacetylase complexes to the H3K4me3 mark to alter histone acetylation and subsequently, gene expression. Here we find that ectopic expression of ING5, the...

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PMID: 28925404
DOI: 10.1038/onc.2017.324

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