MLL5 Orchestrates a Cancer Self-Renewal State by Repressing the Histone Variant H3.3 and Globally Reorganizing Chromatin.

doi:10.1016/j.ccell.2015.10.005

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Article

MLL5 Orchestrates a Cancer Self-Renewal State by Repressing the Histone Variant H3.3 and Globally Reorganizing Chromatin.

Cancer cell - 14 Dec 2015

Gallo Marco, Coutinho Fiona J, Vanner Robert J, Gayden Tenzin, Mack Stephen C, Murison Alex, Remke Marc, Li Ren, Takayama Naoya, Desai Kinjal, Lee Lilian, Lan Xiaoyang, Park Nicole I, Barsyte-Lovejoy Dalia, Smil David, Sturm Dominik, Kushida Michelle M, Head Renee, Cusimano Michael D, Bernstein Mark, Clarke Ian D, Dick John E, Pfister Stefan M, Rich Jeremy N, Arrowsmith Cheryl H, Taylor Michael D, Jabado Nada, Bazett-Jones David P, Lupien Mathieu, Dirks Peter B

Abstract excerpt

Mutations in the histone 3 variant H3.3 have been identified in one-third of pediatric glioblastomas (GBMs), but not in adult tumors. Here we show that H3.3 is a dynamic determinant of functional properties in adult GBM. H3.3 is repressed by mixed lineage leukemia 5 (MLL5) in self-renewing GBM cells. MLL5 is a global epigenetic repressor that orchestrates reorganization of chromatin structure by punctuating...

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PMID: 26626085
DOI: 10.1016/j.ccell.2015.10.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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