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CREB5 promotes the proliferation and self-renewal ability of glioma stem cells

28 Feb 2024

Abstract excerpt

Glioblastoma multiforme (GBM) is the most fatal form of brain cancer in humans, with a dismal prognosis and a median overall survival rate of less than 15 months upon diagnosis. Glioma stem cells (GSCs), have recently been identified as key contributors in both tumor initiation and therapeutic resistance in GBM. Both public dataset analysis and direct differentiation experiments on GSCs have demonstrated that...

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PMID: 38418476
DOI: 10.1038/s41420-024-01873-z

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