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Article

Reciprocal regulation of integrin β4 and KLF4 promotes gliomagenesis through maintaining cancer stem cell traits

18 Jan 2019

Abstract excerpt

BACKGROUND: The dismal prognosis of patients with glioma is largely attributed to cancer stem cells that display pivotal roles in tumour initiation, progression, metastasis, resistance to therapy, and relapse. Therefore, understanding how these populations of cells maintain their stem-like properties is critical in developing effective glioma therapeutics. METHODS: RNA sequencing analysis was used to identify...

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PMID: 30658712
DOI: 10.1186/s13046-019-1034-1

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