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Article

Elevated FOXG1 and SOX2 in glioblastoma enforces neural stem cell identity through transcriptional control of cell cycle and epigenetic regulators.

Genes & development - 15 Apr 2017

Bulstrode Harry, Johnstone Ewan, Marques-Torrejon Maria Angeles, Ferguson Kirsty M, Bressan Raul Bardini, Blin Carla, Grant Vivien, Gogolok Sabine, Gangoso Ester, Gagrica Sladjana, Ender Christine, Fotaki Vassiliki, Sproul Duncan, Bertone Paul, Pollard Steven M

Abstract excerpt

Glioblastoma multiforme (GBM) is an aggressive brain tumor driven by cells with hallmarks of neural stem (NS) cells. GBM stem cells frequently express high levels of the transcription factors FOXG1 and SOX2. Here we show that increased expression of these factors restricts astrocyte differentiation and can trigger dedifferentiation to a proliferative NS cell state. Transcriptional targets include cell cycle and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28465359
DOI: 10.1101/gad.293027.116
PMCID: PMC5435889

Genes

FOXG1
SOX2
FOXO3

Provenance

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