Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human <i>Brat</i> Ortholog <i>TRIM3</i> Is a Tumor Suppressor That Regulates Asymmetric Cell Division in Glioblastoma

20 Jun 2014

Abstract excerpt

Cancer stem cells, capable of self-renewal and multipotent differentiation, influence tumor behavior through a complex balance of symmetric and asymmetric cell divisions. Mechanisms regulating the dynamics of stem cells and their progeny in human cancer are poorly understood. In Drosophila, mutation of brain tumor (brat) leads to loss of normal asymmetric cell division by developing neural cells and results in a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Mechanisms and Therapy
Share to Hippo pathway signaling and YAP/TAZ
Share to interferon and immune responses

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24947043
DOI: 10.1158/0008-5472.can-13-3703

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human <i>Brat</i> Ortholog <i>TRIM3</i> Is a Tumor Suppressor That Regulates Asymmetric Cell Division in GlioblastomaPMID 24947043Read ↗

TRIM 8 regulates stemness in glioblastoma through PIAS 3‐ STAT 3Semantic proximity Read ↗

TRIM24 promotes stemness and invasiveness of glioblastoma cells via activating Sox2 expressionSemantic proximity Read ↗

Single-cell RNA-seq reveals that glioblastoma recapitulates normal brain developmentSemantic proximity Read ↗

Numb Regulates Glioma Stem Cell Fate and Growth by Altering Epidermal Growth Factor Receptor and Skp1-Cullin-F-Box Ubiquitin Ligase ActivitySemantic proximity Read ↗

Mei-P26 regulates microRNAs and cell growth in the Drosophila ovarian stem cell lineage.Semantic proximity Read ↗

Loss of heterozygosity of TRIM3 in malignant gliomas.Semantic proximity Read ↗

Transcription factors ASCL1 and OLIG2 drive glioblastoma initiation and co-regulate tumor cell types and migration.Semantic proximity Read ↗

Distribution of CD133 reveals glioma stem cells self-renew through symmetric and asymmetric cell divisionsSemantic proximity Read ↗

Trim32 Facilitates Degradation of MYCN on Spindle Poles and Induces Asymmetric Cell Division in Human Neuroblastoma CellsSemantic proximity Read ↗

Asymmetry-defective oligodendrocyte progenitors are glioma precursors.Semantic proximity Read ↗

Modeling nervous system tumors with human stem cells and organoidsSemantic proximity Read ↗

The doublesex-related Dmrta2 safeguards neural progenitor maintenance involving transcriptional regulation of Hes1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.