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Article

Distinctive epigenomes characterize glioma stem cells and their response to differentiation cues

27 Mar 2018

Abstract excerpt

BACKGROUND: Glioma stem cells (GSCs) are a subpopulation of stem-like cells that contribute to glioblastoma (GBM) aggressiveness, recurrence, and resistance to radiation and chemotherapy. Therapeutically targeting the GSC population may improve patient survival, but unique vulnerabilities need to be identified. RESULTS: We isolate GSCs from well-characterized GBM patient-derived xenografts (PDX), characterize...

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PMID: 29587824
DOI: 10.1186/s13059-018-1420-6

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