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Article

TRIM 8 regulates stemness in glioblastoma through PIAS 3‐ STAT 3

19 Jan 2017

Abstract excerpt

Glioblastoma (GBM) is the most malignant form of primary brain tumor, and GBM stem-like cells (GSCs) contribute to the rapid growth, therapeutic resistance, and clinical recurrence of these fatal tumors. STAT3 signaling supports the maintenance and proliferation of GSCs, yet regulatory mechanisms are not completely understood. Here, we report that tri-partite motif-containing protein 8 (TRIM8) activates STAT3...

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PMID: 28100038
DOI: 10.1002/1878-0261.12034

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