Structure-dependent impairment of intracellular apolipoprotein E4 trafficking and its detrimental effects are rescued by small-molecule structure correctors.

doi:10.1074/jbc.M110.217380

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Article

Structure-dependent impairment of intracellular apolipoprotein E4 trafficking and its detrimental effects are rescued by small-molecule structure correctors.

The Journal of biological chemistry - 13 May 2011

Brodbeck Jens, McGuire Jim, Liu Zhaoping, Meyer-Franke Anke, Balestra Maureen E, Jeong Dah-eun, Pleiss Mike, McComas Casey, Hess Fred, Witter David, Peterson Scott, Childers Matthew, Goulet Mark, Liverton Nigel, Hargreaves Richard, Freedman Stephen, Weisgraber Karl H, Mahley Robert W, Huang Yadong

Abstract excerpt

Apolipoprotein (apo) E4 is the major genetic risk factor for Alzheimer disease (AD) and likely contributes to neuropathology through various pathways. Here we report that the intracellular trafficking of apoE4 is impaired in Neuro-2a cells and primary neurons, as shown by measuring fluorescence recovery after photobleaching. In Neuro-2a cells, more apoE4 than apoE3 molecules remained immobilized in the...

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PMID: 21454574
DOI: 10.1074/jbc.M110.217380
PMCID: PMC3089564

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