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Article

BLM helicase regulates DNA repair by counteracting RAD51 loading at DNA double-strand break sites.

The Journal of cell biology - 6 Nov 2017

Patel Dharm S, Misenko Sarah M, Her Joonyoung, Bunting Samuel F

Abstract excerpt

The BLM gene product, BLM, is a RECQ helicase that is involved in DNA replication and repair of DNA double-strand breaks by the homologous recombination (HR) pathway. During HR, BLM has both pro- and anti-recombinogenic activities, either of which may contribute to maintenance of genomic integrity. We find that in cells expressing a mutant version of BRCA1, an essential HR factor, ablation of BLM rescues genomic...

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Topics

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Share to BRCA2 Protein
Share to DNA Breaks, Double-Stranded

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genomic Instability

Share to Protein Stability

Share to Rad51 Recombinase

Share to Recombinational DNA Repair

Share to RecQ Helicases

Share to Tumor Suppressor p53-Binding Protein 1

Source

Open in PubMed Open full text

Identifiers

PMID: 28912125
DOI: 10.1083/jcb.201703144
PMCID: PMC5674892

Genes

BLM
RAD51
BRCA1
BRCA2
XRCC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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