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Article

Genetic interactions between BLM and DNA ligase IV in human cells.

The Journal of biological chemistry - 31 Dec 2004

So Sairei, Adachi Noritaka, Lieber Michael R, Koyama Hideki

Abstract excerpt

BLM has been implicated in DNA double-strand break (DSB) repair, but its precise role remains obscure. To explore this, we generated BLM(-/-) and BLM(-/-)LIG4(-/-) cells from the human pre-B cell line Nalm-6. BLM(-/-) cells exhibited retarded growth, increased mutation rates, and hypersensitivity to agents that block replication fork progression. Interestingly, these phenotypes were significantly suppressed by...

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Source

Identifiers

PMID: 15509577
DOI: 10.1074/jbc.M409827200

Genes

BLM
LIG4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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