Article
BLM helicase is activated in BCR/ABL leukemia cells to modulate responses to cisplatin.
Oncogene - 2 Jun 2005
Slupianek Artur, Gurdek Ewa, Koptyra Mateusz, Nowicki Michal O, Siddiqui Khwaja M, Groden Joanna, Skorski Tomasz
Abstract excerpt
Bloom protein (BLM) is a 3'-5' helicase, mutated in Bloom syndrome, which plays an important role in response to DNA double-strand breaks and stalled replication forks. Here, we show that BCR/ABL tyrosine kinase, which also modulates DNA repair capacity, is associated with elevated expression of BLM. Downregulation of BLM by antisense cDNA or dominant-negative mutant inhibits homologous recombination repair (HRR)...
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