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Article

Intra-nuclear trafficking of the BLM helicase to DNA damage-induced foci is regulated by SUMO modification.

Human molecular genetics - 15 May 2005

Eladad Sonia, Ye Tian-Zhang, Hu Peng, Leversha Margaret, Beresten Sergey, Matunis Michael J, Ellis Nathan A

Abstract excerpt

The Bloom syndrome gene, BLM, encodes a RecQ DNA helicase that when absent from the cell results in genomic instability and cancer predisposition. We show here that BLM is a substrate for small ubiquitin-like modifier (SUMO) modification, with lysines at K317, K331, K334 and K347 being preferred sites of modification. Unlike normal BLM, a double mutant BLM protein with lysine to arginine substitutions at residues...

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Topics

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Share to Adenosine Triphosphatases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Fluorescent Antibody Technique

Share to Leukemia, Promyelocytic, Acute

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Source

Identifiers

PMID: 15829507
DOI: 10.1093/hmg/ddi145

Genes

BLM
BRCA1
PML

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence.

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Intra-nuclear trafficking of the BLM helicase to DNA damage-induced foci is regulated by SUMO modification.PMID 15829507Read ↗

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