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Multiple functions of the ALT favorite helicase, BLM

1 Mar 2025

Abstract excerpt

Eukaryotic somatic cells undergo continuous telomere shortening because of end-replication problems. Approximately 10%~15% of human cancers rely on alternative lengthening of telomeres (ALT) to overcome telomere shortening. ALT cells are characterized by persistent telomere DNA replication stress and rely on recombination-based DNA repair pathways for telomere elongation. The Bloom syndrome (BLM) helicase is a...

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PMID: 40025590
DOI: 10.1186/s13578-025-01372-3

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