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Article

Interhomolog recombination and loss of heterozygosity in wild-type and Bloom syndrome helicase (BLM)-deficient mammalian cells.

Proceedings of the National Academy of Sciences of the United States of America - 19 Jul 2011

LaRocque Jeannine R, Stark Jeremy M, Oh Jin, Bojilova Ekaterina, Yusa Kosuke, Horie Kyoji, Takeda Junji, Jasin Maria

Abstract excerpt

Genomic integrity often is compromised in tumor cells, as illustrated by genetic alterations leading to loss of heterozygosity (LOH). One mechanism of LOH is mitotic crossover recombination between homologous chromosomes, potentially initiated by a double-strand break (DSB). To examine LOH associated with DSB-induced interhomolog recombination, we analyzed recombination events using a reporter in mouse embryonic...

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Share to Chromosomes, Mammalian
Share to Crossing Over, Genetic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cytogenetic Analysis

Share to DNA Breaks, Double-Stranded

Share to Electroporation

Share to Gene Conversion

Share to Loss of Heterozygosity

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Source

Open in PubMed Open full text

Identifiers

PMID: 21730139
DOI: 10.1073/pnas.1104421108
PMCID: PMC3141969

Genes

BLM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Interhomolog recombination and loss of heterozygosity in wild-type and Bloom syndrome helicase (BLM)-deficient mammalian cells.PMID 21730139Read ↗

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