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Article

Depletion of the bloom syndrome helicase stimulates homology-dependent repair at double-strand breaks in human chromosomes.

DNA repair - 3 Apr 2011

Wang Yibin, Smith Krissy, Waldman Barbara Criscuolo, Waldman Alan S

Abstract excerpt

Mutation of BLM helicase causes Blooms syndrome, a disorder associated with genome instability, high levels of sister chromatid exchanges, and cancer predisposition. To study the influence of BLM on double-strand break (DSB) repair in human chromosomes, we stably transfected a normal human cell line with a DNA substrate that contained a thymidine kinase (tk)-neo fusion gene disrupted by the recognition site for...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 21300576
DOI: 10.1016/j.dnarep.2011.01.009
PMCID: PMC3062690

Genes

BLM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Depletion of the bloom syndrome helicase stimulates homology-dependent repair at double-strand breaks in human chromosomes.PMID 21300576Read ↗

Intrachromosomal recombination between highly diverged DNA sequences is enabled in human cells deficient in Bloom helicase.Semantic proximity Read ↗

The Bloom's syndrome protein (BLM) interacts with MLH1 but is not required for DNA mismatch repair.Semantic proximity Read ↗

BLM helicase suppresses recombination at G-quadruplex motifs in transcribed genesSemantic proximity Read ↗

Loss of RMI2 Increases Genome Instability and Causes a Bloom-Like Syndrome.Semantic proximity Read ↗

The DNA helicase activity of BLM is necessary for the correction of the genomic instability of bloom syndrome cells.Semantic proximity Read ↗

Deficiency of Bloom syndrome helicase activity is radiomimetic.Semantic proximity Read ↗

Mutation of the murine Bloom's syndrome gene produces global genome destabilization.Semantic proximity Read ↗

Functions of the Bloom Syndrome Helicase N-terminal Intrinsically Disordered RegionSemantic proximity Read ↗

Enhancement of microhomology-mediated genomic rearrangements by transient loss of mouse Bloom syndrome helicase.Semantic proximity Read ↗

Bloom helicase and DNA topoisomerase IIIalpha are involved in the dissolution of sister chromatids.Semantic proximity Read ↗

The BLM-TOP3A-RMI1-RMI2 proximity map reveals that RAD54L2 suppresses sister chromatid exchangesSemantic proximity Read ↗

Genomic instability and cancer: lessons from analysis of Bloom's syndrome.Semantic proximity Read ↗

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