Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Drosophila BLM in double-strand break repair by synthesis-dependent strand annealing.

Science (New York, N.Y.) - 10 Jan 2003

Adams Melissa D, McVey Mitch, Sekelsky Jeff J

Abstract excerpt

Bloom syndrome, characterized by a predisposition to cancer, is caused by mutation of the RecQ DNA helicase gene BLM. The precise function of BLM remains unclear. Previous research suggested that Drosophila BLM functions in the repair of DNA double-strand breaks. Most double-strand breaks in flies are repaired by homologous recombination through the synthesis-dependent strand-annealing pathway. Here, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Damage
Share to DNA Helicases
Share to DNA Repair

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drosophila

Share to Eye Color

Share to Genes, Insect

Share to Terminal Repeat Sequences

Share to Transposases

Source

Identifiers

PMID: 12522255
DOI: 10.1126/science.1077198

Genes

BLM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Drosophila BLM in double-strand break repair by synthesis-dependent strand annealing.PMID 12522255Read ↗

Formation of deletions during double-strand break repair in Drosophila DmBlm mutants occurs after strand invasion.Semantic proximity Read ↗

Loss of the bloom syndrome helicase increases DNA ligase 4-independent genome rearrangements and tumorigenesis in aging Drosophila.Semantic proximity Read ↗

In vivo analysis of Drosophila BLM helicase function during DNA double-strand gap repair.Semantic proximity Read ↗

Functions of the Bloom Syndrome Helicase N-terminal Intrinsically Disordered RegionSemantic proximity Read ↗

Role of the Bloom's syndrome helicase in maintenance of genome stability.Semantic proximity Read ↗

Bloom helicase is involved in DNA surveillance in early S phase in vertebrate cells.Semantic proximity Read ↗

Multiple functions of Drosophila BLM helicase in maintenance of genome stability.Semantic proximity Read ↗

A novel cell-cycle-regulated interaction of the Bloom syndrome helicase BLM with Mcm6 controls replication-linked processes.Semantic proximity Read ↗

An essential DNA strand-exchange activity is conserved in the divergent N-termini of BLM orthologs.Semantic proximity Read ↗

Vertebrate WRNIP1 and BLM are required for efficient maintenance of genome stability.Semantic proximity Read ↗

RecQ helicases: guardian angels of the DNA replication fork.Semantic proximity Read ↗

The Bloom syndrome complex senses RPA-coated single-stranded DNA to restart stalled replication forks.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.