Article
Potential role for the BLM helicase in recombinational repair via a conserved interaction with RAD51.
The Journal of biological chemistry - 1 Jun 2001
Wu L, Davies S L, Levitt N C, Hickson I D
Abstract excerpt
Bloom's syndrome (BS) is an autosomal recessive disorder that predisposes individuals to a wide range of cancers. The gene mutated in BS, BLM, encodes a member of the RecQ family of DNA helicases. The precise role played by these enzymes in the cell remains to be determined. However, genome-wide hyper-recombination is a feature of many RecQ helicase-deficient cells. In eukaryotes, a central step in homologous...
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