Article
RIPK1 mediates a disease-associated microglial response in Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America - 10 Oct 2017
Ofengeim Dimitry, Mazzitelli Sonia, Ito Yasushi, DeWitt Judy Park, Mifflin Lauren, Zou Chengyu, Das Sudeshna, Adiconis Xian, Chen Hongbo, Zhu Hong, Kelliher Michelle A, Levin Joshua Z, Yuan Junying
Abstract excerpt
Dysfunction of microglia is known to play an important role in Alzheimer's disease (AD). Here, we investigated the role of RIPK1 in microglia mediating the pathogenesis of AD. RIPK1 is highly expressed by microglial cells in human AD brains. Using the amyloid precursor protein (APP)/presenilin 1 (PS1) transgenic mouse model, we found that inhibition of RIPK1, using both pharmacological and genetic means, reduced...
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