Article

Cystatin F <i>(Cst7)</i> drives sex-dependent changes in microglia in an amyloid-driven model of Alzheimer’s Disease

2022-11-18

Abstract excerpt

Microglial endolysosomal (dys)function is strongly implicated in neurodegeneration. Transcriptomic studies show that a microglial state characterised by a set of genes involved in endolysosomal function is induced in both mouse Alzheimer’s Disease (AD) models and in human AD brain and that the onset of this state is emphasized in females. Cst7 (encoding protein Cystatin F) is among the most highly upregulated gen...

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Literature Corpus work: 8e8e01ba-786a-5348-8b8e-0da6f2a54387
DOI: 10.1101/2022.11.18.516922

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