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Article

The SHIP1-inflammatory-lipid axis in Alzheimer's disease: from genetic risk to spatiotemporal mechanistic insights.

Journal of neuroinflammation - 22 Apr 2026

Xi Rongjiao, Zheng Xiaobo, Zhao Jing, Fu Yuan

Abstract excerpt

The INPP5D gene, encoding the SHIP1 protein, has been identified as a prominent genetic risk factor for Alzheimer’s disease (AD). However, its multifunctional roles remain complex. SHIP1 serves as a pivotal integrative node linking microglial immune activation with lipid metabolism. This review synthesizes current evidence on the SHIP1-inflammatory-lipid axis, elucidating how its phosphatase and scaffold...

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Share to Alzheimer Disease
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases

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Source

Open in PubMed Open full text

Identifiers

PMID: 42021321
DOI: 10.1186/s12974-026-03819-x
PMCID: PMC13248449

Genes

INPP5D
NLRP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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