Article

The Alzheimer’s disease gene <i>SORL1</i> regulates lysosome function in human microglia

2024-06-25

Abstract excerpt

<h4> Abstract </h4> The SORL1 gene encodes the sortilin related receptor protein SORLA, a sorting receptor that regulates endo-lysosomal trafficking of various substrates. Loss of function variants in SORL1 are causative for Alzheimer’s disease (AD) and decreased expression of SORLA has been repeatedly observed in human AD brains. SORL1 is highly expressed in the central nervous system, including in microglia...

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Literature Corpus work: fdb2d61d-5bec-58e7-ab7b-85178472904b
DOI: 10.1101/2024.06.25.600648

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