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Article

Pulling MscL open via N-terminal and TM1 helices: A computational study towards engineering an MscL nanovalve.

PloS one - 1 Jan 2017

Martinac Adam D, Bavi Navid, Bavi Omid, Martinac Boris

Abstract excerpt

There are great opportunities in the manipulation of bacterial mechanosensitive (MS) ion channels for specific and targeted drug delivery purposes. Recent research has shown that these ion channels have the potential to be converted into nanovalves through clever use of magnetic nanoparticles and magnetic fields. Using a combination of molecular dynamics (MD) simulations and the finite element (FE) modelling,...

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Share to Escherichia coli Proteins
Share to Ion Channels
Share to Lipid Bilayers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mechanotransduction, Cellular

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Identifiers

PMID: 28859093
DOI: 10.1371/journal.pone.0183822
PMCID: PMC5578686

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