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Article

Visualization of the mechanosensitive ion channel MscS under membrane tension.

Nature - 1 Feb 2021

Zhang Yixiao, Daday Csaba, Gu Ruo-Xu, Cox Charles D, Martinac Boris, de Groot Bert L, Walz Thomas

Abstract excerpt

Mechanosensitive channels sense mechanical forces in cell membranes and underlie many biological sensing processes1-3. However, how exactly they sense mechanical force remains under investigation4. The bacterial mechanosensitive channel of small conductance, MscS, is one of the most extensively studied mechanosensitive channels4-8, but how it is regulated by membrane tension remains unclear, even though the...

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PMID: 33568813
DOI: 10.1038/s41586-021-03196-w

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Visualization of the mechanosensitive ion channel MscS under membrane tension.PMID 33568813Read ↗

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The mechanosensitive channel of small conductance (MscS) functions as a Jack-in-the box.Semantic proximity Read ↗

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The cytoplasmic cage domain of the mechanosensitive channel MscS is a sensor of macromolecular crowding.Semantic proximity Read ↗

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