Article
Evidence-based prioritisation and enrichment of genes interacting with metformin in type 2 diabetes.
Diabetologia - 1 Nov 2017
Dawed Adem Y, Ali Ashfaq, Zhou Kaixin, Pearson Ewan R, Franks Paul W
Abstract excerpt
AIMS/HYPOTHESIS: There is an extensive body of literature suggesting the involvement of multiple loci in regulating the action of metformin; most findings lack replication, without which distinguishing true-positive from false-positive findings is difficult. To address this, we undertook evidence-based, multiple data integration to determine the validity of published evidence. METHODS: We (1) built a database of...
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