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Article

Implications of genetic variations, differential gene expression, and allele-specific expression on metformin response in drug-naïve type 2 diabetes.

Journal of endocrinological investigation - 1 Jun 2023

Vohra M, Sharma A R, Mallya S, Prabhu N B, Jayaram P, Nagri S K, Umakanth S, Rai P S

Abstract excerpt

PURPOSE: Metformin is widely used to treat type 2 diabetes mellitus (T2DM) individuals. Clinically, inter-individual variability of metformin response is of significant concern and is under interrogation. In this study, a targeted exome and whole transcriptome analysis were performed to identify predictive biomarkers of metformin response in drug-naïve T2DM individuals. METHODS: The study followed a prospective...

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Identifiers

PMID: 36528847
DOI: 10.1007/s40618-022-01989-y
PMCID: PMC10185588

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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