Article

Multi-layered genetic approaches to identify approved drug targets

2023-03-24

Abstract excerpt

Drugs targeting genes that harbor natural variations associated with the disease the drug is in-dicated for have increased odds to be approved. Various approaches have been proposed to iden-tify likely causal genes for complex diseases, including gene-based genome-wide association stud-ies (GWAS), rare variant burden tests in whole exome sequencing studies (Exome) or integration of GWAS with expression/protein qua...

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Literature Corpus work: a113ea28-acd8-5484-a6ce-c6a0ceb6fee4
DOI: 10.1101/2023.03.21.23285637

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