Article

Leveraging Genetic Correlations to Prioritize Drug Groups for Repurposing in Type 2 Diabetes

2025-06-14

Abstract excerpt

Type 2 diabetes (T2D) is a complex, polygenic disease with substantial health impact. Despite extensive genome-wide association studies (GWAS) identifying risk loci, therapeutic translation remains limited. We applied a Bayesian Linear Regression (BLR) multi-trait gene set model to prioritize druggable gene sets, integrating GWAS summary statistics with drug-gene interaction data from the Drug Gene Interaction Dat...

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Literature Corpus work: 30c26491-35fe-54cc-ace4-29be6b19ca73
DOI: 10.1101/2025.06.13.25329590

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