Article
Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program.
Diabetes - 1 Oct 2010
Jablonski Kathleen A, McAteer Jarred B, de Bakker Paul I W, Franks Paul W, Pollin Toni I, Hanson Robert L, Saxena Richa, Fowler Sarah, Shuldiner Alan R, Knowler William C, Altshuler David, Florez Jose C
Abstract excerpt
OBJECTIVE: Genome-wide association studies have begun to elucidate the genetic architecture of type 2 diabetes. We examined whether single nucleotide polymorphisms (SNPs) identified through targeted complementary approaches affect diabetes incidence in the at-risk population of the Diabetes Prevention Program (DPP) and whether they influence a response to preventive interventions. RESEARCH DESIGN AND METHODS: We...
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