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Article

Prioritization of genes associated with type 2 diabetes mellitus for functional studies.

Nature reviews. Endocrinology - 1 Aug 2023

Tan Wei Xuan, Sim Xueling, Khoo Chin Meng, Teo Adrian K K

Abstract excerpt

Existing therapies for type 2 diabetes mellitus (T2DM) show limited efficacy or have adverse effects. Numerous genetic variants associated with T2DM have been identified, but progress in translating these findings into potential drug targets has been limited. Here, we describe the tools and platforms available to identify effector genes from T2DM-associated coding and non-coding variants and prioritize them for...

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PMID: 37169822
DOI: 10.1038/s41574-023-00836-1

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