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Article

Using EHR-Linked Biobank Data to Study Metformin Pharmacogenomics.

Studies in health technology and informatics - 1 Jan 2015

Breitenstein Matthew K, Simon Gyorgy, Ryu Euijung, Armasu Sebastian M, Weinshilboum Richard M, Wang Liewei, Pathak Jyotishman

Abstract excerpt

Metformin is a commonly prescribed diabetes medication whose mechanism of action is poorly understood. In this study we utilized EHR-linked biobank data to elucidate the impact of genomic variation on glycemic response to metformin. Our study found significant gene- and SNP-level associations within the beta-2 subunit of the heterotrimeric adenosine monophosphate-activated protein kinase complex. Using EHR...

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Identifiers

PMID: 25991289
PMCID: PMC5051541

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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