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Article

Pathways targeted by antidiabetes drugs are enriched for multiple genes associated with type 2 diabetes risk.

Diabetes - 1 Apr 2015

Segrè Ayellet V, Wei Nancy, Altshuler David, Florez Jose C

Abstract excerpt

Genome-wide association studies (GWAS) have uncovered >65 common variants associated with type 2 diabetes (T2D); however, their relevance for drug development is not yet clear. Of note, the first two T2D-associated loci (PPARG and KCNJ11/ABCC8) encode known targets of antidiabetes medications. We therefore tested whether other genes/pathways targeted by antidiabetes drugs are associated with T2D. We compiled a...

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Share to Databases, Genetic
Share to Diabetes Mellitus, Type 2
Share to NFKB1 gene

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Genetic Predisposition to Disease

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Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 25368101
DOI: 10.2337/db14-0703
PMCID: PMC4375079

Genes

ABCC8
ACSL1
KCNJ11
NFKB1
PPARG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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