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Article

Prioritization of therapeutic targets for dyslipidemia using integrative multi-omics and multi-trait analysis.

Cell reports. Medicine - 19 Sept 2023

Kim Min Seo, Song Minku, Kim Beomsu, Shim Injeong, Kim Dan Say, Natarajan Pradeep, Do Ron, Won Hong-Hee

Abstract excerpt

Drug targets with genetic support are several-fold more likely to succeed in clinical trials. We introduce a genetic-driven approach based on causal inferences that can inform drug target prioritization, repurposing, and adverse effects of using lipid-lowering agents. Given that a multi-trait approach increases the power to detect meaningful variants/genes, we conduct multi-omics and multi-trait analyses,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37582372
DOI: 10.1016/j.xcrm.2023.101112
PMCID: PMC10518515

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